The prevalence and patterns of pharyngoesophageal dysmotility in patients with early stage Parkinson's disease
Identifieur interne : 000513 ( Main/Exploration ); précédent : 000512; suivant : 000514The prevalence and patterns of pharyngoesophageal dysmotility in patients with early stage Parkinson's disease
Auteurs : Hye Young Sung [Corée du Sud] ; Joong-Seok Kim [Corée du Sud] ; Kwang-Soo Lee [Corée du Sud] ; Yeong-In Kim [Corée du Sud] ; In-Uk Song [Corée du Sud] ; Sung-Woo Chung [Corée du Sud] ; Dong-Won Yang [Corée du Sud] ; Yu Kyung Cho [Corée du Sud] ; Jae Myung Park [Corée du Sud] ; In Seok Lee [Corée du Sud] ; Sang Woo Kim [Corée du Sud] ; In-Sik Chung [Corée du Sud] ; Myung-Gyu Choi [Corée du Sud]Source :
- Movement Disorders [ 0885-3185 ] ; 2010-10-30.
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Abstract
Dysphagia occurs in the majority of patients with Parkinson's disease (PD) and is known to correlate with abnormalities of oropharyngeal function. The aim of this study was to evaluate pharyngoesophageal activity in patients with early‐stage PD. Newly diagnosed PD patients with a symptom duration not exceeding 3 years were included. All PD patients were questioned about symptoms of dysphagia and underwent combined multichannel intraluminal impedance manometry and multiple rapid swallow tests. Fifty‐four patients (22 men and 32 women, 67.1 ± 10.3 years) were enrolled. The duration of Parkinsonian motor symptoms was 11.5 ± 8.8 months, the Hoehn and Yahr stage was 1.6 ± 0.4, and the total Unified Parkinson's Disease Rating Scale was 25.1 ± 18.6. Esophageal manometry in the liquid swallow and viscous swallow tests was abnormal in 22 (40.7%) and 31 (67.4%) patients, respectively. Although manometric abnormalities were more common in patients with more severe dysphagia symptoms, many patients with no or minimal symptoms also had manometric abnormalities. Repetitive deglutition significantly correlated with failed peristalsis and incomplete bolus transit. Abnormal responses to multiple rapid swallow tests were found in 33 out of 54 patients; 29 with incomplete inhibition (repetitive contraction) and 4 with failed peristalsis. These results suggest that the majority of patients with early‐stage PD showed pharyngeal and esophageal dysfunction even before clinical manifestations of dysphagia, which may reflect selective involvement of either the brain stem or the esophageal myenteric plexus in early‐stage PD. © 2010 Movement Disorder Society.
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DOI: 10.1002/mds.23290
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505, Banpo‐dong, Seocho‐gu, Seoul, South KoreaMyung‐Gyu Choi, Department of Internal Medicine, The Catholic University of Korea, Seoul St. Mary's hospital, 505, Banpo‐dong, Seocho‐gu, Seoul, 137‐701</wicri:regionArea><wicri:noRegion>137‐701</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2010-10-30">2010-10-30</date><biblScope unit="volume">25</biblScope><biblScope unit="issue">14</biblScope><biblScope unit="page" from="2361">2361</biblScope><biblScope unit="page" to="2368">2368</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">2ED9A219D1EBBB988250077BBFBB951199B37167</idno><idno type="DOI">10.1002/mds.23290</idno><idno type="ArticleID">MDS23290</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>dysphagia</term><term>esophageal manometry</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Dysphagia occurs in the majority of patients with Parkinson's disease (PD) and is known to correlate with abnormalities of oropharyngeal function. The aim of this study was to evaluate pharyngoesophageal activity in patients with early‐stage PD. Newly diagnosed PD patients with a symptom duration not exceeding 3 years were included. All PD patients were questioned about symptoms of dysphagia and underwent combined multichannel intraluminal impedance manometry and multiple rapid swallow tests. Fifty‐four patients (22 men and 32 women, 67.1 ± 10.3 years) were enrolled. The duration of Parkinsonian motor symptoms was 11.5 ± 8.8 months, the Hoehn and Yahr stage was 1.6 ± 0.4, and the total Unified Parkinson's Disease Rating Scale was 25.1 ± 18.6. Esophageal manometry in the liquid swallow and viscous swallow tests was abnormal in 22 (40.7%) and 31 (67.4%) patients, respectively. Although manometric abnormalities were more common in patients with more severe dysphagia symptoms, many patients with no or minimal symptoms also had manometric abnormalities. Repetitive deglutition significantly correlated with failed peristalsis and incomplete bolus transit. Abnormal responses to multiple rapid swallow tests were found in 33 out of 54 patients; 29 with incomplete inhibition (repetitive contraction) and 4 with failed peristalsis. These results suggest that the majority of patients with early‐stage PD showed pharyngeal and esophageal dysfunction even before clinical manifestations of dysphagia, which may reflect selective involvement of either the brain stem or the esophageal myenteric plexus in early‐stage PD. © 2010 Movement Disorder Society.</div></front></TEI><affiliations><list><country><li>Corée du Sud</li></country><settlement><li>Séoul</li></settlement></list><tree><country name="Corée du Sud"><noRegion><name sortKey="Sung, Hye Young" sort="Sung, Hye Young" uniqKey="Sung H" first="Hye Young" last="Sung">Hye Young Sung</name></noRegion><name sortKey="Cho, Yu Kyung" sort="Cho, Yu Kyung" uniqKey="Cho Y" first="Yu Kyung" last="Cho">Yu Kyung Cho</name><name sortKey="Choi, Myung Yu" sort="Choi, Myung Yu" uniqKey="Choi M" first="Myung-Gyu" last="Choi">Myung-Gyu Choi</name><name sortKey="Choi, Myung Yu" sort="Choi, Myung Yu" uniqKey="Choi M" first="Myung-Gyu" last="Choi">Myung-Gyu Choi</name><name sortKey="Chung, In Ik" sort="Chung, In Ik" uniqKey="Chung I" first="In-Sik" last="Chung">In-Sik Chung</name><name sortKey="Chung, Sung Oo" sort="Chung, Sung Oo" uniqKey="Chung S" first="Sung-Woo" last="Chung">Sung-Woo Chung</name><name sortKey="Kim, Joong Eok" sort="Kim, Joong Eok" uniqKey="Kim J" first="Joong-Seok" last="Kim">Joong-Seok Kim</name><name sortKey="Kim, Joong Eok" sort="Kim, Joong Eok" uniqKey="Kim J" first="Joong-Seok" last="Kim">Joong-Seok Kim</name><name sortKey="Kim, Sang Woo" sort="Kim, Sang Woo" uniqKey="Kim S" first="Sang Woo" last="Kim">Sang Woo Kim</name><name sortKey="Kim, Yeong N" sort="Kim, Yeong N" uniqKey="Kim Y" first="Yeong-In" last="Kim">Yeong-In Kim</name><name sortKey="Lee, In Seok" sort="Lee, In Seok" uniqKey="Lee I" first="In Seok" last="Lee">In Seok Lee</name><name sortKey="Lee, Kwang Oo" sort="Lee, Kwang Oo" uniqKey="Lee K" first="Kwang-Soo" last="Lee">Kwang-Soo Lee</name><name sortKey="Park, Jae Myung" sort="Park, Jae Myung" uniqKey="Park J" first="Jae Myung" last="Park">Jae Myung Park</name><name sortKey="Song, In K" sort="Song, In K" uniqKey="Song I" first="In-Uk" last="Song">In-Uk Song</name><name sortKey="Sung, Hye Young" sort="Sung, Hye Young" uniqKey="Sung H" first="Hye Young" last="Sung">Hye Young Sung</name><name sortKey="Yang, Dong On" sort="Yang, Dong On" uniqKey="Yang D" first="Dong-Won" last="Yang">Dong-Won Yang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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